VU 0546110
Tocris Bioscience, part of Bio-Techne | Catalog # 7956
Selective SLO3 potassium channel inhibitor
Key Product Details
Description
Selective SLO3 potassium channel inhibitor
Product Description
VU 0546110 is a selective inhibitor of the sperm-specific potassium channel SLO3 (IC50 = 64 μM). It shows 40-fold selectivity over SLO1. It completely blocks heterologous SLO3 currents and endogenous K+ currents. VU 0546110 inhibits sperm hyperpolarisation and prevents its hyperactivated mobility.Product Specifications
Molecular Weight
461.64
Formula
C24H31NO4S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-[4-[[(4-Methoxyphenyl)thio]methyl]-1-piperidinyl]-2-[4-[(1-methylethyl)sulfonyl]phenyl]ethanone
CAS Number
1421523-00-3
PubChem ID
71800954
InChI Key
IUFAHCWQEABYHO-UHFFFAOYSA-N
SMILES
O=C(CC1=CC=C(S(=O)(C(C)C)=O)C=C1)N2CCC(CC2)CSC3=CC=C(C=C3)OC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.16 | 100 | |
| Ethanol | 23.08 | 50 |
Preparing Stock Solutions
for VU 0546110
The following data is based on the product molecular weight 461.64
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.17 mL | 10.83 mL | 21.66 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.33 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.17 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lyon A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function. Proc.Natl.Acad.Sci.U.S.A. 2023 PMID: 36649421
Product Specific Notices for VU 0546110
For research use only
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