VU 0469650 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5379
Potent and selective negative allosteric modulator of mGlu1 receptors
Key Product Details
Description
Potent and selective negative allosteric modulator of mGlu1 receptors
Product Description
VU 0469650 hydrochloride is a potent and selective negative allosteric modulator of mGlu1 (IC50 = 99 nM). Exhibits >100-fold selectivity for mGlu1 over mGlu2-8 and 68 other GPCRs, ion channels, kinases and transporters. Brain penetrant.Product Specifications
Molecular Weight
400.94
Formula
C22H28N4O.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile hydrochloride
CAS Number
1443748-47-7
PubChem ID
71680759
InChI Key
YENVAZRENOYZGQ-GUIQYPADSA-N
SMILES
O=C(N4CCN(C5=C(C#N)N=CC=C5)C[C@H]4C)C12CC(C3)CC(CC3C2)C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.09 | 100 | |
| Ethanol | 20.05 | 50 |
Preparing Stock Solutions
for VU 0469650 hydrochloride
The following data is based on the product molecular weight 400.94
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.49 mL | 12.47 mL | 24.94 mL |
| 5 mM | 0.50 mL | 2.49 mL | 4.99 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.49 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lovell N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: Identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. Bioorg.Med.Chem.Lett. 2013 PMID: 23727046
Product Specific Notices for VU 0469650 hydrochloride
For research use only
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