VU 0255035

Name: VU 0255035
Brand: Tocris Bioscience
SKU: 3727

Tocris Bioscience, part of Bio-Techne | Catalog # 3727

Citations (31)

COA / SDS

Highly selective M1 antagonist

Key Product Details

Description:	Highly selective M₁ antagonist
Chemical Name:	N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	432.52

View Full Technical Details for VU 0255035

Technical Data
Citations

Biological Activity for VU 0255035

VU 0255035 is a highly selective muscarinic M₁ antagonist (K_i = 14.87 nM). Targets the M₁ orthosteric site with greater than 75-fold selectivity over the other receptor subtypes. Reduces pilocarpine-induced seizures in mice. Brain penetrant.

Technical Data for VU 0255035

M. Wt	432.52
Formula	C₁₈H₂₀N₆O₃S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1135243-19-4
PubChem ID	24768606
InChi Key	WXDHQWPQLKGANZ-UHFFFAOYSA-N
Smiles	O=C(CCNS(C4=CC=CC3=NSN=C34)(=O)=O)N(CC2)CCN2C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VU 0255035

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	8.65	20

Preparing Stock Solutions for VU 0255035

The following data is based on the product molecular weight 432.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.56 mL	57.80 mL	115.60 mL
1 mM	2.31 mL	11.56 mL	23.12 mL
2 mM	1.16 mL	5.78 mL	11.56 mL
10 mM	0.23 mL	1.16 mL	2.31 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for VU 0255035

References are publications that support the biological activity of the product.

Sheffler A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning. Mol.Pharmacol. 2009 PMID: 19407080