VU 0240551

Name: VU 0240551
Brand: Tocris Bioscience
SKU: 3888

Tocris Bioscience, part of Bio-Techne | Catalog # 3888

Citations (28)

COA / SDS

KCC2 inhibitor

Discontinued Product

3888 has been discontinued. View all KCC2 Inhibitors products.

Key Product Details

Description:	KCC2 inhibitor
Chemical Name:	N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide
Purity:	≥99% (HPLC)
Molecular Weight:	342.43

View Full Technical Details for VU 0240551

Technical Data
Citations

Biological Activity for VU 0240551

VU 0240551 is an inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC₅₀ = 560 nM for K⁺ uptake assay in KCC2-overexpressing cells). Exhibits selectivity over the Na-K-2Cl cotransporter, NKCCl. Also inhibits hERG and L-type Ca²⁺ channels.

Technical Data for VU 0240551

M. Wt	342.43
Formula	C₁₆H₁₄N₄OS₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	893990-34-6
PubChem ID	7211972
InChi Key	WJRWSLORVIHRNX-UHFFFAOYSA-N
Smiles	O=C(NC3=NC(C)=CS3)CSC(C=C2)=NN=C2C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for VU 0240551

References are publications that support the biological activity of the product.

Delpire Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorg.Med.Chem.Lett. 2012 PMID: 22727639
Deisz Effects of VU0240551, a novel KCC2 antagonist, and DIDS on chloride homeostasis of neocortical neurons from rats and humans. Neuroscience 2014 PMID: 25086309
Delpire Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc.Natl.Acad.Sci.USA 2009 PMID: 19279215

VU 0240551

Tocris Bioscience, part of Bio-Techne | Catalog # 3888

Key Product Details

Biological Activity for VU 0240551

Technical Data for VU 0240551

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for VU 0240551

Product Documents for VU 0240551

COA

Certificate of Analysis

SDS

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