VU 0240551

Tocris Bioscience, part of Bio-Techne | Catalog # 3888

KCC2 inhibitor
Discontinued Product
3888 has been discontinued. View all KCC2 Inhibitors products.

Key Product Details

Description

KCC2 inhibitor

View all KCC2 Inhibitors »

Product Description

VU 0240551 is an inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 560 nM for K+ uptake assay in KCC2-overexpressing cells). Exhibits selectivity over the Na-K-2Cl cotransporter, NKCCl. Also inhibits hERG and L-type Ca2+ channels.

Product Specifications

Molecular Weight

342.43

Formula

C16H14N4OS2

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide

CAS Number

893990-34-6

PubChem ID

7211972

InChI Key

WJRWSLORVIHRNX-UHFFFAOYSA-N

SMILES

O=C(NC3=NC(C)=CS3)CSC(C=C2)=NN=C2C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.24 100
Ethanol 8.56 25

Preparing Stock Solutions for VU 0240551

The following data is based on the product molecular weight 342.43

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.92 mL 14.60 mL 29.20 mL
5 mM 0.58 mL 2.92 mL 5.84 mL
10 mM 0.29 mL 1.46 mL 2.92 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for VU 0240551

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for VU 0240551

For research use only

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