VU 0134992
Tocris Bioscience, part of Bio-Techne | Catalog # 6877
Kir4.1 blocker
Key Product Details
Description
Kir4.1 blocker
Product Description
VU 0134992 is a Kir4.1 potassium channel blocker (IC50 = 0.97 μM). Displays 10-fold selectivity for Kir4.1 over Kir4.1/5.1 concatemeric channels and >30-fold selectivity over Kir1.1, 2.1 and 2.2. Increases urine output and urinary Na+ and K+ excretion in volume-loaded rats.Product Specifications
Molecular Weight
411.38
Formula
C20H31BrN2O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
CAS Number
755002-90-5
PubChem ID
1319582
InChI Key
OTTDLWFVHQYRDA-UHFFFAOYSA-N
SMILES
CC(C)C1=CC(Br)=C(OCC(=O)NC2CC(C)(C)NC(C)(C)C2)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.14 | 100 | |
| Ethanol | 41.14 | 100 |
Preparing Stock Solutions
for VU 0134992
The following data is based on the product molecular weight 411.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.43 mL | 12.15 mL | 24.31 mL |
| 5 mM | 0.49 mL | 2.43 mL | 4.86 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.43 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kharade Discovery, characterization, and effects on renal fluid and electrolyte excretion of the Kir4.1 potassium channel pore blocker, VU0134992. Mol.Pharmacol. 2018 PMID: 29895592
Product Specific Notices for VU 0134992
For research use only
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