VTP 27999 trifluoroacetate
Tocris Bioscience, part of Bio-Techne | Catalog # 5563
Highly potent and selective renin inhibitor
Key Product Details
Description
Highly potent and selective renin inhibitor
Product Description
VTP 27999 trifluoroacetate is a highly potent and selective renin inhibitor (IC50 = 0.47 nM). Displays >1000-fold selectivity over related and unrelated off-targets. Blocks renin-stimulated ERK1/2 phosphorylation in vascular smooth muscle cells. Exhibits a different mode of action to aliskiren (Cat. No. 5491).Product Specifications
Molecular Weight
639.10
Formula
C26H41ClN4O5.CF3CO2H
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
Methyl N-[2-[(R)-(3-Chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]carbamate trifluoroacetate
CAS Number
1013937-63-7
PubChem ID
121513870
InChI Key
SYWYSVAEGXHOJO-VIEYARBJSA-N
SMILES
ClC1=CC=CC([C@H](OCCNC(OC)=O)[C@]2([H])CCCN(C(NC[C@@H](NC)C[C@H]3CCCOC3)=O)C2)=C1.OC(C(F)(F)F)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 63.91 | 100 | |
| DMSO | 63.91 | 100 |
Preparing Stock Solutions
for VTP 27999 trifluoroacetate
The following data is based on the product molecular weight 639.10
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.56 mL | 7.82 mL | 15.65 mL |
| 5 mM | 0.31 mL | 1.56 mL | 3.13 mL |
| 10 mM | 0.16 mL | 0.78 mL | 1.56 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.31 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lu Renin inhibitor VTP-27999 differs from aliskiren: focus on their intracellular accumulation and the (pro)renin receptor. J.Hypertens. 2014 PMID: 24637873
- Jia Discovery of VTP-27999, an alkyl amine renin inhibitor with potential for clinical utility. ACS Med.Chem.Lett. 2011 PMID: 24900262
Product Specific Notices for VTP 27999 trifluoroacetate
For research use only
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