VT 104
Tocris Bioscience, part of Bio-Techne | Catalog # 8176
Potent pan-TEAD inhibitor
Product Description
VT 104 is a potent pan-TEAD (transcriptional enhanced associate domain) inhibitor (IC50 = 10.4 nM). VT 104 inhibits YAP/TAZ-TEAD promoted gene transcription by preventing the association between YAP/TAZ and TEAD. VT 104 blocks TEAD auto-palmitoylation. In vitro, VT 104 inhibits NF2-deficient mesothelioma cell proliferation, and growth of subcutaneous tumor xenografts in vivo. VT 104 is orally bioavailable.Product Specifications
Molecular Weight
420.43
Formula
C25H19F3N2O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[(1S)-1-(2-Pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxamide
CAS Number
2417718-25-1
PubChem ID
146909371
InChI Key
AAZUPSFRSHFTGV-INIZCTEOSA-N
SMILES
C(N[C@@H](C)C1=CC=CC=N1)(=O)C2=CC3=C(C(=CC=C3)C4=CC=C(C(F)(F)F)C=C4)C=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.04 | 100 | |
| Ethanol | 21.02 | 50 |
Preparing Stock Solutions
for VT 104
The following data is based on the product molecular weight 420.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.38 mL | 11.89 mL | 23.79 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.76 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Tang Small molecule inhibitors of TEAD auto-palmitoylation selectively inhibit proliferation and tumor growth of NF2-deficient mesothelioma. Mol.Cancer Ther. 2021 PMID: 33850002
Product Specific Notices for VT 104
For research use only
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