VO-OHpic
Tocris Bioscience, part of Bio-Techne | Catalog # 3591
Potent PTEN inhibitor
Key Product Details
Description
Potent PTEN inhibitor
Product Description
VO-OHpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) (IC50 = 35 nM). Displays selectivity for PTEN over cysteine-based phosphatases such as SopB, MTM, PTPβ and SAC (IC50 values are 588 nM, 4.03, 57.5 and >10 μM respectively). Increases PIP2 and PIP3 levels; also increases Akt translocation in NIH/3T3 fibroblasts. Blocks the immunosuppressant activity of IDO-activated Tregs. Promotes antitumor inflammatory response in combination with immunotherapy and enhances anticancer chemotherapy in tumor-bearing mice.Product Specifications
Molecular Weight
361.16
Formula
C12H10N2O8V
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(OC-6-45)-Aqua(3-hydroxy-2-pyridinecarboxylato-κ-N1,κO2)[3-(hydroxy-κO)-2-pyridinecarboxylato(2-)-κO2]oxovanadate(1-),hydrogen
CAS Number
675848-25-6
PubChem ID
90488861
InChI Key
WUAQQAGTKWKWKQ-UHFFFAOYSA-K
SMILES
OC1=C2C([O-][V+2]3(O)([O-]C(C4=NC=CC=C4[O-]3)=O)([N]2=CC=C1)=O)=O.[H+]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.12 | 100 |
Preparing Stock Solutions
for VO-OHpic
The following data is based on the product molecular weight 361.16
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.77 mL | 13.84 mL | 27.69 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.54 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.77 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sharma The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Sci.Adv. 2015 PMID: 26601142
- Rosivatz A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem.Biol. 2006 PMID: 17240976
Product Specific Notices for VO-OHpic
For research use only
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