Vismodegib

Name: Vismodegib
Brand: Tocris Bioscience
SKU: 7710

Tocris Bioscience, part of Bio-Techne | Catalog # 7710

Citations (5)

COA / SDS

Potent hedgehog pathway inhibitor

Key Product Details

Description:	Potent hedgehog pathway inhibitor
Chemical Name:	2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	421.3

View Full Technical Details for Vismodegib

Technical Data
Citations

Biological Activity for Vismodegib

Vismodegib is a potent hedgehog pathway inhibitor (IC₅₀ = 3 nM). It causes tumor regressions in allograft medulloblastoma mice model and tumor growth inhibition in a xenograft mouse models of colorectal cancer. Vismodegib is orally bioavailable.

Technical Data for Vismodegib

M. Wt	421.3
Formula	C₁₉H₁₄Cl₂N₂O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	879085-55-9
PubChem ID	24776445
InChi Key	BPQMGSKTAYIVFO-UHFFFAOYSA-N
Smiles	O=C(NC=1C=CC(Cl)=C(C1)C2=NC=CC=C2)C3=CC=C(C=C3Cl)S(=O)(=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Vismodegib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.13	100

Preparing Stock Solutions for Vismodegib

The following data is based on the product molecular weight 421.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.87 mL	23.74 mL
5 mM	0.47 mL	2.37 mL	4.75 mL
10 mM	0.24 mL	1.19 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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Reconstitution Calculator

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References for Vismodegib

References are publications that support the biological activity of the product.

Wong Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor. Xenobiotica 2009 PMID: 19845436
Wong Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation. Clin.Cancer Res. 2011 PMID: 21610148
Robarge GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg.Med.Chem.Lett. 2009 PMID: 19716296