Vigabatrin

Name: Vigabatrin
Brand: Tocris Bioscience
SKU: 0808

Catalog # 0808 | Tocris Bioscience a Bio-Techne Brand

Citations (2)

COA / SDS

GABA-T inhibitor

Key Product Details

Description:	GABA-T inhibitor
Alternative Names:	(±)-γ-Vinyl GABA
Chemical Name:	4-Aminohexenoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	129.16

View Full Technical Details for Vigabatrin

Technical Data
Citations (2) / Reviews

Biological Activity for Vigabatrin

Vigabatrin is a selective GABA-T (transaminase) inhibitor. Anticonvulsant.

Technical Data for Vigabatrin

M. Wt	129.16
Formula	C₆H₁₁NO₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	68506-86-5
PubChem ID	5665
InChi Key	PJDFLNIOAUIZSL-UHFFFAOYSA-N
Smiles	NC(C=C)CCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Vigabatrin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	12.92	100

Preparing Stock Solutions for Vigabatrin

The following data is based on the product molecular weight 129.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	7.74 mL	38.71 mL	77.42 mL
5 mM	1.55 mL	7.74 mL	15.48 mL
10 mM	0.77 mL	3.87 mL	7.74 mL
50 mM	0.15 mL	0.77 mL	1.55 mL

Molarity Calculator

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Reconstitution Calculator

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References for Vigabatrin

References are publications that support the biological activity of the product.

Schmid Vigabatrin modulates benzodiazepine receptor activity in vivo: a positron emission tomography study in baboon. J.Pharmacol.Exp.Ther. 1996 PMID: 8786578
Halonen Effects of vigab. (γ-vinyl GABA) on neurotransmission-related amino acids and on GABA and benzodiazepine receptor binding in rats. Epilepsia 1991 PMID: 1672276
Larsson Differential effect of gamma-vinyl GABA and valproate on GABA transaminase from cultured neurones and astrocytes. Neuropharmacology 1986 PMID: 3092125

Citations for Vigabatrin (2)

Showing 1 - 2 of 2 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Vigabatrin include:

Walters et al. (2019) Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use-limiting visual field defects. Pharmacol Res Perspect. 7:e00456
PMID: 30631446
Héja et al. (2009) Glutamate uptake triggers transporter-mediated GABA release from astrocytes. Stem Cells Dev. 4:e7153
PMID: 19777062

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