Venlafaxine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2917
5-HT and NA reuptake inhibitor (SNRI)
Key Product Details
Description
5-HT and NA reuptake inhibitor (SNRI)
Alternative Names
Wy 45030
Product Description
Venlafaxine hydrochloride is a dual serotonin/noradrenalin re-uptake inhibitor that displays ~ 30-fold higher affinity for SERT than NET (Ki values are 82 and 2480 nM respectively). Antidepressant; increases swimming and climbing behavior in the forced-swim test in rats.Product Specifications
Molecular Weight
313.86
Formula
C17H27NO2.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride
CAS Number
99300-78-4
PubChem ID
62923
InChI Key
QYRYFNHXARDNFZ-UHFFFAOYSA-N
SMILES
OC2(CCCCC2)C(CN(C)C)C1=CC=C(OC)C=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 31.39 | 100 | |
| DMSO | 15.69 | 50 |
Preparing Stock Solutions
for Venlafaxine hydrochloride
The following data is based on the product molecular weight 313.86
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.19 mL | 15.93 mL | 31.86 mL |
| 5 mM | 0.64 mL | 3.19 mL | 6.37 mL |
| 10 mM | 0.32 mL | 1.59 mL | 3.19 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Gould A comparison of the chronic treatment effects of venlaf. and other antidepressants on serotonin and NE transporters. Biol.Psychiatry 2006 PMID: 16140280
- Bymaster Comparative affinity of dulox. and venlaf. for serotonin and NE transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 2001 PMID: 11750180
- Magalas The serotonin/noradrenaline reuptake inhibitor venlaf. attenuates acquistion, but not maintenance, of intravenous self-administration of heroin in rats. Eur.J.Pharmacol. 2005 PMID: 16325805
Product Specific Notices for Venlafaxine hydrochloride
For research use only
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