Vandetanib

Name: Vandetanib
Brand: Tocris Bioscience
SKU: 7497

Tocris Bioscience, part of Bio-Techne | Catalog # 7497

Citations (4)

COA / SDS

Potent VEGFR-2 inhibitor, also inhibits EGFR and RET oncoproteins activity

Key Product Details

Description:	Potent VEGFR-2 inhibitor, also inhibits EGFR and RET oncoproteins activity
Chemical Name:	N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine
Purity:	≥98% (HPLC)
Molecular Weight:	475.36

View Full Technical Details for Vandetanib

Technical Data
Citations

Biological Activity for Vandetanib

Vandetanib is a potent VEGFR-2 inhibitor (IC₅₀ = 0.04 μM), and inhibitor of EGFR (IC₅₀ = 0.5 μM). Vandetanib potently inhibits (IC₅₀ = 100 nM) RET oncoprotein activity in human thyroid cancer. Vandetanib displays anti-angiogenic properties in human nasopharyngeal carcinoma in mice model. Vandetanib is orally available and effective in vivo.

Technical Data for Vandetanib

M. Wt	475.36
Formula	C₂₂H₂₄BrFN₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	443913-73-3
PubChem ID	3081361
InChi Key	UHTHHESEBZOYNR-UHFFFAOYSA-N
Smiles	FC1=CC(Br)=CC=C1NC=2N=CN=C3C=C(OCC4CCN(C)CC4)C(OC)=CC32

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Vandetanib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	23.77	50

Preparing Stock Solutions for Vandetanib

The following data is based on the product molecular weight 475.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.21 mL	21.04 mL	42.07 mL
2.5 mM	0.84 mL	4.21 mL	8.41 mL
5 mM	0.42 mL	2.10 mL	4.21 mL
25 mM	0.08 mL	0.42 mL	0.84 mL

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References for Vandetanib

References are publications that support the biological activity of the product.

Hennequin Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors. J.Med.Chem. 2002 PMID: 11881999
Cui Resonance imaging for monitoring the early response to ZD6474 from nasopharyngeal carcinoma in nude mouse. Sci.Rep. 2015 PMID: 26574153
Ancker Multikinase inhibitor treatment in thyroid cancer. Int.J.Mol.Sci. 2019 PMID: 31861373
Carlomagno ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer res. 2002 PMID: 12499271