UNC 8732
Tocris Bioscience, part of Bio-Techne | Catalog # 8118
Potent NSD2 Degrader
Product Description
UNC 8732 is a potent nuclear receptor binding SET domain-containing 2 (NSD2) Degrader (DC50 = 60 nM; Dmax = 97%). NSD2 degradation is driven by the aldehyde metabolite of UNC 8732 in vitro. Recruits FBX022 and SCF complexes for degradation to reduce H3K36me2 levels in cells. Reduces viability and restores glucocorticoid sensitivity of NSD2 p.E1099K mutant ALL cells.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC8732 page on the SGC website.Product Specifications
Molecular Weight
723.75
Formula
C35H39N5O5.CF3CO2H
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[[4-[[[2-(6-Amino-1-oxohexyl)-1,2,3,4-tetrahydro-6-isoquinolinyl]amino]carbonyl]phenyl]methyl]-N-cyclopropyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-7-carboxamide trifluoroacetate
CAS Number
2929304-06-1
InChI Key
HFQMCVDNCFEJSF-UHFFFAOYSA-N
SMILES
O=C(C1=CC=C(CN(C2CC2)C(C3=CC=C4NC(COC4=C3)=O)=O)C=C1)NC5=CC=C6C(CCN(C6)C(CCCCCN)=O)=C5.OC(C(F)(F)F)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 72.37 | 100 | |
| Ethanol | 72.37 | 100 |
Preparing Stock Solutions
for UNC 8732
The following data is based on the product molecular weight 723.75
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.38 mL | 6.91 mL | 13.82 mL |
| 5 mM | 0.28 mL | 1.38 mL | 2.76 mL |
| 10 mM | 0.14 mL | 0.69 mL | 1.38 mL |
| 50 mM | 0.03 mL | 0.14 mL | 0.28 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Product Specific Notices for UNC 8732
For research use only
Loading...
Loading...