UNC 6934
Tocris Bioscience, part of Bio-Techne | Catalog # 7183
Antagonizes PWWP1 interaction with nucleosomal H3K36me2, alters NSD2 nucleolar localization
Key Product Details
Description
Antagonizes PWWP1 interaction with nucleosomal H3K36me2, alters NSD2 nucleolar localization
Product Description
UNC 6934 binds to the N-terminal proline-tryptophan-tryptophan-proline (PWWP) domain of nuclear receptor-binding SET domain-containing 2 (NSD2). UNC 6934 inhibits PWWP1 interaction with nucleosomal H3K36me2 (IC50 = 104 nM) by occupying the canonical H3K36me2-binding pocket of PWWP1. It selectively binds endogenous NSD2 in cells and causes accumulation of endogenous NSD2 in the nucleolus.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 6934 probe summary on the SGC website.Product Specifications
Molecular Weight
443.46
Formula
C24H21N5O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-Cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-2H-1,4-benzoxazine-7-carboxamide
CAS Number
2561494-77-5
PubChem ID
146676966
InChI Key
KOZGEDUWAQFVAV-UHFFFAOYSA-N
SMILES
O=C(C1=CC=C(N2)C(OCC2=O)=C1)N(C3CC3)CC4=CC=C(C(NC5=NC=NC=C5)=O)C=C4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.87 | 20 |
Preparing Stock Solutions
for UNC 6934
The following data is based on the product molecular weight 443.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.27 mL | 56.37 mL | 112.75 mL |
| 1 mM | 2.25 mL | 11.27 mL | 22.55 mL |
| 2 mM | 1.13 mL | 5.64 mL | 11.27 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.25 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sankaran A PWWP domain of histone-lysine N-methyltransferase NSD2 binds to dimethylated Lys-36 of histone H3 and regulates NSD2 function at chromatin. J.Biol.Chem. 2016 PMID: 26912663
- Dilworth A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nat.Chem.Biol. 2022 PMID: 34782742
Product Specific Notices for UNC 6934
For research use only
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