UNC 2327
Tocris Bioscience, part of Bio-Techne | Catalog # 5057
Allosteric inhibitor of PRMT3
Discontinued Product
5057 has been discontinued.
View all Protein Arginine Methyltransferase Inhibitors products.
Key Product Details
Description
Allosteric inhibitor of PRMT3
Product Description
UNC 2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 230 nM). Noncompetitive with both the peptide substrate and cofactor.Product Specifications
Molecular Weight
319.38
Formula
C14H17N5O2S
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
N-1,2,3-Benzothiadiazol-6-yl-N'-[2-oxo-2-(1-piperidinyl)ethyl]urea
CAS Number
1426152-53-5
PubChem ID
71583615
InChI Key
MYTRGTBDVGKKRO-UHFFFAOYSA-N
SMILES
O=C(NCC(N3CCCCC3)=O)NC1=CC=C(N=NS2)C2=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.94 | 100 |
Preparing Stock Solutions
for UNC 2327
The following data is based on the product molecular weight 319.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.13 mL | 15.66 mL | 31.31 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.13 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Liu Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. J.Med.Chem. 2013 PMID: 23445220
Product Specific Notices for UNC 2327
For research use only
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