UCPH 101
Tocris Bioscience, part of Bio-Techne | Catalog # 3490
Selective non-substrate EAAT1 inhibitor
Key Product Details
Description
Selective non-substrate EAAT1 inhibitor
Product Description
UCPH 101 is a selective non-substrate inhibitor of EAAT1 (IC50 values are 660, >300000 and >300000 nM for EAAT1, EAAT2 and EAAT3 respectively). Also demonstrates no significant inhibition at EAAT4 or EAAT5 in a patch-clamp electrophysiology assay (at final concentration up to 10 μM).Product Specifications
Molecular Weight
422.48
Formula
C27H22N2O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile
CAS Number
1118460-77-7
PubChem ID
25223366
InChI Key
YBMGNDPBARCLFT-UHFFFAOYSA-N
SMILES
NC2=C(C#N)C(C3=CC=C(OC)C=C3)C1=C(O2)CC(C4=C(C=CC=C5)C5=CC=C4)CC1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.56 | 25 |
Preparing Stock Solutions
for UCPH 101
The following data is based on the product molecular weight 422.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 9.47 mL | 47.34 mL | 94.68 mL |
| 1.25 mM | 1.89 mL | 9.47 mL | 18.94 mL |
| 2.5 mM | 0.95 mL | 4.73 mL | 9.47 mL |
| 12.5 mM | 0.19 mL | 0.95 mL | 1.89 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Abrahamsen Allosteric modulation of an excitatory amino acid transporter: The subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain. J.Neurosci. 2013 PMID: 23325245
- Erichsen Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101). J.Med.Chem. 2010 PMID: 20857912
- Bunch Excitatory amino acid transporters as potential drug targets. Exp.Opin.Ther.Targets
- Jensen Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1. J.Med.Chem. 2009 PMID: 19161278
Product Specific Notices for UCPH 101
For research use only
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