UCB 9386
Tocris Bioscience, part of Bio-Techne | Catalog # 8914
Potent and selective CNS penetrant NUAK1 inhibitor
Key Product Details
Description
Potent and selective CNS penetrant NUAK1 inhibitor
Product Description
UCB 9386 is a potent and selective central nervous system penetrant NUAK1 (NUAK family SnF1-like kinase-1) inhibitor (pIC50= 10.1). Kinome selectivity measured in the diversity panel shows that only Jak2 and Nuak2 are inhibited more than 50% at 10 nM. In vivo, UCB 9386 exhibits high brain penetrance.Product Specifications
Molecular Weight
478.56
Formula
C27H26N8O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(R)-7-(Imidazo[1,2-b]pyridazin-3-yl)-3-(6-methyl-2,6-diazaspiro[3.3]heptan-2-yl)-1-(1-phenylethyl)pyrido[3,4-b]pyrazin-2(1H)-one
PubChem ID
172676957
InChI Key
XYKISMBNQVUKPW-GOSISDBHSA-N
SMILES
C[C@@H](N1C(C(N2CC3(C2)CN(C3)C)=NC4=C1C=C(C5=CN=C6C=CC=NN65)N=C4)=O)C7=CC=CC=C7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.86 | 100 | |
| Ethanol | 47.86 | 100 |
Preparing Stock Solutions
for UCB 9386
The following data is based on the product molecular weight 478.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.09 mL | 10.45 mL | 20.90 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.18 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.09 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Poullennec Discovery of UCB9386: a potent, selective, and brain-penetrant Nuak1 inhibitor suitable for in vivo pharmacological studies. J Med Chem 2024 PMID: 39588908
Product Specific Notices for UCB 9386
For research use only
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