UCB 35625
Tocris Bioscience, part of Bio-Techne | Catalog # 2757
Potent CCR1 and CCR3 antagonist
Key Product Details
Description
Potent CCR1 and CCR3 antagonist
Product Description
UCB 35625 is a potent chemokine CCR1 and CCR3 receptor antagonist. Inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants (IC50 values are 9.57 and 93.8 nM respectively). Antagonizes CCR3-mediated entry of HIV-1 isolate 89.6 into NP-2 cells (IC50 = 57 nM).Isomer also available.
Product Specifications
Molecular Weight
655.44
Formula
C30H37Cl2IN2O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1,4-trans-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide
CAS Number
202796-42-7
PubChem ID
6918496
InChI Key
FOAFBMYSXIGAOX-LQGGPMKRSA-N
SMILES
ClC1=CC=C(OC(C=CC(Cl)=C3)=C3C2C(N[C@H]4CC[N@@+](C/C5=C/CCCCCC5)(CC)CC4)=O)C2=C1.ClC6=CC=C(OC(C=CC(Cl)=C8)=C8C7C(N[C@@H]9CC[N@+](C/C%10=C/CCCCCC%10)(CC)CC9)=O)C7=C6.[I-].[I-]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 65.54 | 100 | |
| Ethanol | 32.77 | 50 |
Preparing Stock Solutions
for UCB 35625
The following data is based on the product molecular weight 655.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.53 mL | 7.63 mL | 15.26 mL |
| 5 mM | 0.31 mL | 1.53 mL | 3.05 mL |
| 10 mM | 0.15 mL | 0.76 mL | 1.53 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.31 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lopes de Mendonca Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist. J.Biol.Chem. 2005 PMID: 15548526
- Sabroe A small molecule antagonist of chemokine receptors CCR1 and CCR3. J.Biol.Chem. 2000 PMID: 10854442
Product Specific Notices for UCB 35625
For research use only
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