U0124
Tocris Bioscience, part of Bio-Techne | Catalog # 1868
Inactive analog of U0126 (Cat. No. 1144)
Discontinued Product
1868 has been discontinued.
View all MEK Inhibitors products.
Product Description
U0124 is an inactive analog of U0126 (Cat. No. 1144). Does not inhibit MEK at concentrations up to 100 μM. Used as a negative control.Active Analog also available.
Product Specifications
Molecular Weight
226.31
Formula
C8H10N4S2
Storage
Store at RT
Chemical Name
Bis[amino(methylthio)methylene]butanedinitrile
CAS Number
108923-79-1
PubChem ID
5842955
InChI Key
LBQNBMSPTURKGS-KQQUZDAGSA-N
SMILES
N/C(SC)=C(\C(C#N)=C(SC)/N)/C#N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.63 | 100 |
Preparing Stock Solutions
for U0124
The following data is based on the product molecular weight 226.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.42 mL | 22.09 mL | 44.19 mL |
| 5 mM | 0.88 mL | 4.42 mL | 8.84 mL |
| 10 mM | 0.44 mL | 2.21 mL | 4.42 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.88 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Fitzgerald Regulation of voltage-dependent calcium channels in rat sensory neurones involves a Ras-mitogen-activated protein kinase pathway. J.Physiol. 2000 PMID: 10990531
- Sekar Concerted transcriptional activation of the low density lipoprotein receptor gene by Ins and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase A, phosphatidylinositol 3-kinase, and mitogen-activated pro Endocrinology 2001 PMID: 11416012
- Favata Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J.Biol.Chem. 1998 PMID: 9660836
Product Specific Notices for U0124
For research use only
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