U 104

Name: U 104
Brand: Tocris Bioscience
SKU: 4540

Tocris Bioscience, part of Bio-Techne | Catalog # 4540

COA / SDS

Potent carbonic anhydrase (CA) IX and XII inhibitor

Discontinued Product

4540 has been discontinued. View all Carbonic Anhydrase Inhibitors products.

Key Product Details

Description:	Potent carbonic anhydrase (CA) IX and XII inhibitor
Chemical Name:	4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzesulfonamide
Purity:	≥99% (HPLC)
Molecular Weight:	309.32

View Full Technical Details for U 104

Technical Data
Citations

Biological Activity for U 104

U 104 is a potent carbonic anhydrase (CA) inhibitor (K_i values are 4.5, 45.1, 5080 and 9640 nM for CA XII, CA IX, CA I and CA II respectively in MDA-MB-231 cells). Inhibits tumor metastasis in the rat 4T1 metastasis model.

Technical Data for U 104

M. Wt	309.32
Formula	C₁₃H₁₂FN₃O₃S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	178606-66-1
PubChem ID	310360
InChi Key	YJQZNWPYLCNRLP-UHFFFAOYSA-N
Smiles	FC1=CC=C(NC(NC2=CC=C(S(=O)(N)=O)C=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for U 104

References are publications that support the biological activity of the product.

Lou Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 2011 PMID: 21415165

U 104

Tocris Bioscience, part of Bio-Techne | Catalog # 4540

Key Product Details

Biological Activity for U 104

Technical Data for U 104

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for U 104

Product Documents for U 104

COA

Certificate of Analysis

SDS

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