TY 52156

Tocris Bioscience, part of Bio-Techne | Catalog # 5328

S1P3 receptor antagonist
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Key Product Details

Description

S1P3 receptor antagonist

View all Sphingosine-1-phosphate Receptor Antagonists »

Product Description

TY 52156 is an S1P3 receptor antagonist (Ki = 110 nM); inhibits S1P-induced Ca2+ release in HUVEC cells. Suppresses FTY-720-induced S1P3 receptor-mediated bradycardia in vivo. Also inhibits S1P-induced breast cancer stem cell expansion in vitro. Orally bioavailable.

Product Specifications

Molecular Weight

364.27

Formula

C18H19Cl2N3O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide

CAS Number

934369-14-9

PubChem ID

16046248

InChI Key

XONRRGIRSGNWFP-UHFFFAOYSA-N

SMILES

ClC1=CC=C(/N=C(NNC2=CC=C(Cl)C=C2)/C(C(C)(C)C)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.43 100
Ethanol 36.43 100

Preparing Stock Solutions for TY 52156

The following data is based on the product molecular weight 364.27

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.73 mL 27.45 mL
5 mM 0.55 mL 2.75 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.75 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for TY 52156

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TY 52156

For research use only

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