TWS 119

Product Description

TWS 119 is a potent inhibitor of glycogen synthase kinase-3β (IC₅₀ = 30 nM). TWS 119 inhibits both GSK3α and GSK3β in vitro (IC₅₀ = 88 nM and 410 nM, respectively). TWS 119 induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells at 400 nM. TWS 119 enhances the proliferation and survival of γδ T-cells, and induces differentiation of CD8+ T cells towards a stem cell-like memory T cell phenotype at 2.5 μM.

Solubility

Preparing Stock Solutions for TWS 119

The following data is based on the product molecular weight 318.33

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.14 mL	15.71 mL	31.41 mL
5 mM	0.63 mL	3.14 mL	6.28 mL
10 mM	0.31 mL	1.57 mL	3.14 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Gattinoni Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells. Nat.Med. 2009 PMID: 19525962
• Forget Stimulation of Wnt/β-catenin pathway in human CD8+ T lymphocytes from blood and lung tumors leads to a shared young/memory phenotype. PLoS One 2012 PMID: 22859966
• Zeng Glycogen synthase kinase 3 regulates PAX3-FKHR-mediated cell proliferation in human alveolar rhabdomyosarcoma cells. Biochem.Biophys.Res.Commun. 2009 PMID: 19995556