TUG 891

Tocris Bioscience, part of Bio-Techne | Catalog # 4601

COA / SDS

Potent and selective FFA4 (GPR120) agonist

Key Product Details

Description:	Potent and selective FFA4 (GPR120) agonist
Chemical Name:	4-[(4-Fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-benzenepropanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	364.41

View Full Technical Details for TUG 891

Technical Data
Citations

Biological Activity for TUG 891

TUG 891 is a potent FFA4 (GPR120) agonist (pEC₅₀ values are 7.36 and 7.77 for human and mouse GPR120 respectively). Selective for GPR120 over free fatty acid receptors (pEC₅₀ = 4.19 for FFA1; displays no activity at FFA2 or FFA3). Cell permeable.

Licensing Information

Sold under license from the University of Southern Denmark.

Compound Libraries for TUG 891

TUG 891 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TUG 891

M. Wt	364.41
Formula	C₂₃H₂₁FO₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1374516-07-0
PubChem ID	57522038
InChi Key	LPGBXHWIQNZEJB-UHFFFAOYSA-N
Smiles	FC1=CC(COC2=CC=C(CCC(O)=O)C=C2)=C(C3=CC=C(C)C=C3)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TUG 891

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.44	100

Preparing Stock Solutions for TUG 891

The following data is based on the product molecular weight 364.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.74 mL	13.72 mL	27.44 mL
5 mM	0.55 mL	2.74 mL	5.49 mL
10 mM	0.27 mL	1.37 mL	2.74 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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References for TUG 891

References are publications that support the biological activity of the product.

Shimpukade Discovery of a potent and selective GPR120 agonist. J.Med.Chem. 2012 PMID: 22519963