Troglitazone

Name: Troglitazone
Brand: Tocris Bioscience
SKU: 3114
Price: 176 USD

Catalog # 3114 | Tocris Bioscience a Bio-Techne Brand

Citations (3)

COA / SDS

Selective PPARγ agonist; antidiabetic agent

Key Product Details

Description:	Selective PPARγ agonist; antidiabetic agent
Alternative Names:	Rezulin
Chemical Name:	5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
Purity:	≥98% (HPLC)
Molecular Weight:	441.54

View Full Technical Details for Troglitazone

Biological Activity for Troglitazone

Troglitazone is a selective PPARγ receptor agonist (EC₅₀ values are 780 and 555 nM at murine and human PPARγ receptors respectively). Displays no activity at PPARα or PPARδ receptors. Antidiabetic agent; exerts potent glucose-lowering effects in insulin-resistant diabetic mice. Displays anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Also inhibits cell growth of hematopoietic cell lines. Inhibits lamellipodia formation and actin polymerization.

Compound Libraries for Troglitazone

Troglitazone is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Troglitazone

M. Wt	441.54
Formula	C₂₄H₂₇NO₅S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	97322-87-7
PubChem ID	5591
InChi Key	GXPHKUHSUJUWKP-UHFFFAOYSA-N
Smiles	CC1=C2C(CCC(COC3=CC=C(CC4C(NC(S4)=O)=O)C=C3)(C)O2)=C(C)C(O)=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Troglitazone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.15	100

Preparing Stock Solutions for Troglitazone

The following data is based on the product molecular weight 441.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.32 mL	22.65 mL
5 mM	0.45 mL	2.26 mL	4.53 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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References for Troglitazone

References are publications that support the biological activity of the product.

Kodera Ligand type-specific interactions of peroxisome-proliferator-activated receptor γ with transcriptional coactivators. J.Biol.Chem. 2000 PMID: 10944516
Willson The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 2000 PMID: 10691680
Fujimura Effects of troglitazone on the growth and differentiation of hematopoietic cell lines. Int.J.Oncol. 1998 PMID: 9824642
Lee and Olefsky Acute effects of troglitazone on in vivo Ins action in normal rats. Metabolism 1995 PMID: 7666790

Citations for Troglitazone (3)

Showing 1 - 3 of 3 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Troglitazone include:

Ross et al. (2017) Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and sora. Cell Chem Biol. 24:813
PMID: 28625738
Bisikirska et al. (2016) Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression. Cancer Res. 76:664
PMID: 26589882
Hegde et al. (2015) Critical Role of Mast Cells and Peroxisome Proliferator-Activated Receptor γ in the Induction of Myeloid-Derived Suppressor Cells by Marijuana Cannabidiol In Vivo. J Immunol. 194:5211
PMID: 25917103

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Showing 1 - 3 of 3 citations Showing All

Product Documents for Troglitazone

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.