TRAP-6
Tocris Bioscience, part of Bio-Techne | Catalog # 3497
PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist
Key Product Details
Description
PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist
Alternative Names
Thrombin receptor activator peptide 6
Product Description
TRAP-6 is a peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR1) that acts as a PAR1 agonist. Stimulates platelet aggregation (EC50 = 0.8 μM), promotes intracellular Ca2+ mobilization and induces rapid phosphodiesterase 3A (PDE3A) phosphorylation in vitro.Product Specifications
Molecular Weight
748.88
Formula
C34H56N10O9
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
141136-83-6
PubChem ID
9831933
InChI Key
HAGOWCONESKMDW-FRSCJGFNSA-N
SMILES
[H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Kaufmann PAR 1-type thrombin receptors are involved in thrombin-induced calcium signaling in human meningioma cells. J.Neurooncol. 1999 PMID: 10421070
- Hunter Protein kinase C-mediated phosphorylation and activation of PDE3A regulates cAMP levels in human platelets. J.Biol.Chem. 2009 PMID: 19261611
- Vassallo Structure-function relationships in the activation of platelet thrombin receptors by receptor derived peptides. J.Biol.Chem. 1992 PMID: 1313429
Product Specific Notices for TRAP-6
For research use only
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