TransMoDE 3 Biotin

Name: TransMoDE 3 Biotin
Brand: Tocris Bioscience
SKU: 8829

Tocris Bioscience, part of Bio-Techne | Catalog # 8829

COA / SDS

Biotinylated angiopep-2, induces internalization and degradation of streptavidin in brain cell lines

Key Product Details

Description:	Biotinylated angiopep-2, induces internalization and degradation of streptavidin in brain cell lines
Purity:	≥95% (HPLC)
Molecular Weight:	2611.88

View Full Technical Details for TransMoDE 3 Biotin

Technical Data
Citations

Biological Activity for TransMoDE 3 Biotin

TransMoDE 3 Biotin is a biotinylated peptide capable of inducing both the degradation of target protein via lysosomal proteolysis and their bidirectional transcytosis of streptavidin across the blood-brain barrier. TransMoDE 3 Biotin is derived from the peptide Angiopep-2 (Cat. No. 8828).

Technical Data for TransMoDE 3 Biotin

M. Wt	2611.88
Formula	C₁₁₈H₁₆₇N₃₁O₃₅S
Single Letter Sequence	TFFYGGSRGKRNNFKTEEY (Modifications: Thr-1 = N-terminal Ac, Lys-10 = N(ε)-Ac-Lys, Lys-15 = N(ε)-Biotin-Lys
Storage	Store at -20°C
Purity	≥95% (HPLC)
InChi Key	SDTCWCCIHKRCLZ-MKHRACNQSA-N
Smiles	O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=C(C=C3)O)C(NCC(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCNC(C)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCCCNC(CCCC[C@@H]5SC[C@@](N6)([H])[C@]5([H])NC6=O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC7=CC=C(C=C7)O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TransMoDE 3 Biotin

Solubility

Soluble to 1mg/ml in water

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References for TransMoDE 3 Biotin

References are publications that support the biological activity of the product.

Howell Bifunctional Molecules That Induce Both Targeted Degradation and Transcytosis of Extracellular Proteins in Brain Cells. J Am Chem Soc 2024 PMID: 38855935