TPCA-1
Tocris Bioscience, part of Bio-Techne | Catalog # 2559
Potent, selective inhibitor of IKKβ
Key Product Details
Description
Potent, selective inhibitor of IKKβ
Product Description
TPCA-1 is a potent, selective inhibitor of IκB kinase (IKK) β (IC50 = 17.9 nM) that displays > 22-fold selectivity over IKKα and > 550-fold selectivity over other kinases and enzymes. Inhibits production of pro-inflammatory cytokines in vitro and in vivo and inhibits NF-κB nuclear localization. Reduces the severity and onset of collagen-induced arthritis; anti-inflammatory.Product Specifications
Molecular Weight
279.29
Formula
C12H10FN3O2S
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide
CAS Number
507475-17-4
PubChem ID
9903786
InChI Key
SAYGKHKXGCPTLX-UHFFFAOYSA-N
SMILES
NC(=O)NC1=C(C=C(S1)C1=CC=C(F)C=C1)C(N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.92 | 100 |
Preparing Stock Solutions
for TPCA-1
The following data is based on the product molecular weight 279.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.58 mL | 17.90 mL | 35.81 mL |
| 5 mM | 0.72 mL | 3.58 mL | 7.16 mL |
| 10 mM | 0.36 mL | 1.79 mL | 3.58 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Birrell IK-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma. Am.J.Respir.Crit.Care Med. 2005 PMID: 16002568
- Birrell IκB kinase-2-independent and-dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic. Mol.Pharmacol. 2006 PMID: 16517756
- Podolin Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IκB kinase 2, TPCA-1 (2-[aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and J.Pharmacol.Exp.Ther. 2005 PMID: 15316093
Product Specific Notices for TPCA-1
For research use only
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