TP 003

Tocris Bioscience, part of Bio-Techne | Catalog # 4414

GABAA partial agonist; acts at benzodiazepine site
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Key Product Details

Description

GABAA partial agonist; acts at benzodiazepine site

View all GABA-A Receptor Agonists »

Product Description

TP 003 is a GABAA receptor partial agonist that demonstrates affinity for the benzodiazepine site. Potentiates GABAA α3 response with high efficacy. Produces anxiolytic-like effects in rodent elevated plus maze via action at GABAA α2 subtype receptors. Also evokes GABAA α1 mediated sedation and GABAA α3 mediated muscle relaxation in mice.

Product Specifications

Molecular Weight

407.39

Formula

C23H16F3N3O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2',4-Difluoro-5'-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]-pyridin-3-yl]-[1,1'-biphenyl]-2-carbonitrile

CAS Number

628690-75-5

PubChem ID

10001434

InChI Key

SJMMDWXJSSJHOQ-UHFFFAOYSA-N

SMILES

FC1=C(C(C)(O)C)C=CN2C1=NC=C2C3=CC=C(F)C(C4=CC=C(F)C=C4C#N)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.74 100
Ethanol 20.37 50

Preparing Stock Solutions for TP 003

The following data is based on the product molecular weight 407.39

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.27 mL 24.55 mL
5 mM 0.49 mL 2.45 mL 4.91 mL
10 mM 0.25 mL 1.23 mL 2.45 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for TP 003

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TP 003

For research use only

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