Tilfrinib
Tocris Bioscience, part of Bio-Techne | Catalog # 5579
Potent and selective breast tumor kinase (Brk) inhibitor
Key Product Details
Description
Potent and selective breast tumor kinase (Brk) inhibitor
Product Description
Tilfrinib is a potent and selective breast tumor kinase (Brk, also known as tyrosine-protein kinase 6, PTK6) inhibitor (IC50 = 3.15 nM). Exhibits >1000-fold selectivity for Brk over a panel of other kinases. Inhibits proliferation of breast cancer cells in vitro.Licensing Information
Sold under license from Martin-Luther-Universität-Halle-WittenburgProduct Specifications
Molecular Weight
275.30
Formula
C17H13N3O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-(9H-Pyrido[2,3-b]indol-4-ylamino)phenol
CAS Number
1600515-49-8
PubChem ID
76332983
InChI Key
RXPZOSHFGJWSLQ-UHFFFAOYSA-N
SMILES
OC1=CC=CC(NC2=C3C(NC4=CC=CC=C43)=NC=C2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.53 | 100 |
Preparing Stock Solutions
for Tilfrinib
The following data is based on the product molecular weight 275.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.63 mL | 18.16 mL | 36.32 mL |
| 5 mM | 0.73 mL | 3.63 mL | 7.26 mL |
| 10 mM | 0.36 mL | 1.82 mL | 3.63 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.73 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mahmoud Discovery of 4-anilino α-carbolines as novel Brk inhibitors. Bioorg.Med.Chem.Lett. 2014 PMID: 24650640
Product Specific Notices for Tilfrinib
For research use only
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