Thalidomide, propargyl
Tocris Bioscience, part of Bio-Techne | Catalog # 6685
Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs
Key Product Details
Description
Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs
Product Description
Thalidomide, propargyl is a click-activated Thalidomide (Cat.No. 0652); can be used as a precursor to a PROTAC® that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with an alkyne functional handle at a position known not to significantly affect binding to cereblon, for ready click conjugation to a linker/target protein ligand.Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Require a different derivative? Get in touch.
Usage Guidelines
This product is provided for use in onward chemistry. Suitable solvents can be used.Product Specifications
Molecular Weight
312.28
Formula
C16H12N2O5
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
2-(2,6-Dioxo-3-piperidinyl)-4-(2-propyn-1-yloxy)-1H-isoindole-1,3(2H)-dione
CAS Number
2098487-39-7
PubChem ID
132118478
InChI Key
NOGQTNDSZFYNTM-UHFFFAOYSA-N
SMILES
O=C1N(C(C2=C(C=CC=C12)OCC#C)=O)C3CCC(NC3=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wurz A "click chemistry platform" for the rapid rynthesis of bispecific molecules for inducing protein degradation. J.Med.Chem. 2018 PMID: 28378579
Product Specific Notices for Thalidomide, propargyl
For research use only
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