TH 10785
Tocris Bioscience, part of Bio-Techne | Catalog # 7778
OGG1 activator
Product Description
TH 10785 is an 8-oxo guanine DNA glycosylase 1 (OGG1) activator. It binds in the active site of OGG1 and increases its recruitment to oxidative DNA damage and its repair.Product Specifications
Molecular Weight
267.38
Formula
C17H21N3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-Cyclohexyl-2-cyclopropyl-4-quinazolinamine
CAS Number
1002801-51-5
PubChem ID
8078523
InChI Key
ZQMGQZOHIDOPCQ-UHFFFAOYSA-N
SMILES
C1(N=C(C2CC2)N=C3NC4CCCCC4)=C3C=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.74 | 100 | |
| Ethanol | 26.74 | 100 |
Preparing Stock Solutions
for TH 10785
The following data is based on the product molecular weight 267.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.74 mL | 18.70 mL | 37.40 mL |
| 5 mM | 0.75 mL | 3.74 mL | 7.48 mL |
| 10 mM | 0.37 mL | 1.87 mL | 3.74 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.75 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Michel Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Science 2022 PMID: 35737787
Product Specific Notices for TH 10785
For research use only
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