TH 10785

Name: TH 10785
Brand: Tocris Bioscience
SKU: 7778

Tocris Bioscience, part of Bio-Techne | Catalog # 7778

COA / SDS

OGG1 activator

Key Product Details

Description:	OGG1 activator
Chemical Name:	N-Cyclohexyl-2-cyclopropyl-4-quinazolinamine
Purity:	≥98% (HPLC)
Molecular Weight:	267.38

View Full Technical Details for TH 10785

Technical Data
Citations

Biological Activity for TH 10785

TH 10785 is an 8-oxo guanine DNA glycosylase 1 (OGG1) activator. It binds in the active site of OGG1 and increases its recruitment to oxidative DNA damage and its repair.

Technical Data for TH 10785

M. Wt	267.38
Formula	C₁₇H₂₁N₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1002801-51-5
PubChem ID	8078523
InChi Key	ZQMGQZOHIDOPCQ-UHFFFAOYSA-N
Smiles	C1(N=C(C2CC2)N=C3NC4CCCCC4)=C3C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TH 10785

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.74	100
	ethanol	26.74	100

Preparing Stock Solutions for TH 10785

The following data is based on the product molecular weight 267.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.74 mL	18.70 mL	37.40 mL
5 mM	0.75 mL	3.74 mL	7.48 mL
10 mM	0.37 mL	1.87 mL	3.74 mL
50 mM	0.07 mL	0.37 mL	0.75 mL

Molarity Calculator

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Reconstitution Calculator

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References for TH 10785

References are publications that support the biological activity of the product.

Michel Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Science 2022 PMID: 35737787