TGN 020
Tocris Bioscience, part of Bio-Techne | Catalog # 5425
Aquaporin 4 (AQP4) channel blocker
Key Product Details
Description
Aquaporin 4 (AQP4) channel blocker
Product Description
TGN 020 is an aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.Product Specifications
Molecular Weight
206.22
Formula
C8H6N4OS
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide
CAS Number
51987-99-6
PubChem ID
4173511
InChI Key
AGEGZHOPKZFKBP-UHFFFAOYSA-N
SMILES
O=C(NC1=NN=CS1)C2=CN=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.12 | 20 |
Preparing Stock Solutions
for TGN 020
The following data is based on the product molecular weight 206.22
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 24.25 mL | 121.23 mL | 242.46 mL |
| 1 mM | 4.85 mL | 24.25 mL | 48.49 mL |
| 2 mM | 2.42 mL | 12.12 mL | 24.25 mL |
| 10 mM | 0.48 mL | 2.42 mL | 4.85 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Igarashi Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport 2013 PMID: 23462267
- Igarashi and Huber Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol.Sci. 2011 PMID: 20924629
- Huber Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg.Med.Chem. 2009 PMID: 18182301
Product Specific Notices for TGN 020
For research use only
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