Terbinafine hydrochloride

Name: Terbinafine hydrochloride
Brand: Tocris Bioscience
SKU: 6484

Tocris Bioscience, part of Bio-Techne | Catalog # 6484

Citations (2)

COA / SDS

Selective K2P9.1 (TASK-3) activator; also inhibits fungal squalene epoxidase

Key Product Details

Description:	Selective K_2P9.1 (TASK-3) activator; also inhibits fungal squalene epoxidase
Chemical Name:	N-[(2E)-6,6-Dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	327.89

View Full Technical Details for Terbinafine hydrochloride

Technical Data
Citations

Biological Activity for Terbinafine hydrochloride

Terbinafine hydrochloride is a selective TASK3 activator (pEC₅₀ = 6.2). Exhibits >10-fold selectivity for TASK3 over TREK2, TRESK, THIK1 and TASK2. Also inhibits TWIK1 (pIC₅₀ = 5.69). Also antifungal; inhibits fungal sterol biosynthesis by inhibition of squalene epoxidase.

Technical Data for Terbinafine hydrochloride

M. Wt	327.89
Formula	C₂₁H₂₅N.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	78628-80-5
PubChem ID	5282481
InChi Key	BWMISRWJRUSYEX-SZKNIZGXSA-N
Smiles	CN(CC1=CC=CC2=C1C=CC=C2)C/C=C/C#CC(C)(C)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Terbinafine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.79	100
	water	3.28	10 with gentle warming

Preparing Stock Solutions for Terbinafine hydrochloride

The following data is based on the product molecular weight 327.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.05 mL	15.25 mL	30.50 mL
5 mM	0.61 mL	3.05 mL	6.10 mL
10 mM	0.30 mL	1.52 mL	3.05 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

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References for Terbinafine hydrochloride

References are publications that support the biological activity of the product.

Wright Terbinafine is a novel and selective activator of the two-pore domain potassium channel TASK3. Biochem.Biophys.Res.Commun. 2017 PMID: 28882594
Petranyi Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. Science 1984 PMID: 6547247