Terazosin hydrochloride

Name: Terazosin hydrochloride
Brand: Tocris Bioscience
SKU: 1506
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1506

(1)

Citations (13)

COA / SDS

α1 antagonist; PGK1 activator

Key Product Details

Description:	α₁ antagonist; PGK1 activator
Chemical Name:	1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-piperazine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	423.9

View Full Technical Details for Terazosin hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Terazosin hydrochloride

Terazosin hydrochloride is a selective α₁ antagonist. Increases phosphoglycerate kinase 1 (PGK1) activity (K_d = 2.9 μM). Upregulates glucose metabolism and increases ATP production. In an in vitro model of GI disease, terazosin reduces inflammation and protects against oxidative damage. Neuroprotective in in vivo models of ALS and Parkinson's Disease. Antihypertensive following oral or intravenous administration in vivo.

Technical Data for Terazosin hydrochloride

M. Wt	423.9
Formula	C₁₉H₂₅N₅O₄.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	63074-08-8
PubChem ID	44383
InChi Key	IWSWDOUXSCRCKW-UHFFFAOYSA-N
Smiles	Cl.COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N1CCN(CC1)C(=O)C1CCCO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Terazosin hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	8.48	20 with gentle warming

Preparing Stock Solutions for Terazosin hydrochloride

The following data is based on the product molecular weight 423.9.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.80 mL	58.98 mL	117.95 mL
1 mM	2.36 mL	11.80 mL	23.59 mL
2 mM	1.18 mL	5.90 mL	11.80 mL
10 mM	0.24 mL	1.18 mL	2.36 mL

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References for Terazosin hydrochloride

References are publications that support the biological activity of the product.

Hancock Actions of tera. and its enantiomers at subtypes of α1- and α2-adrenoceptors in vitro. J.Recept.Signal Transduct.Res. 1995 PMID: 8673721
Maruyama Comparison of displacemental potencies of tera. enantiomers for α₁-adrenoceptor subtypes. Biol.Pharm.Bull. 1994 PMID: 7820122
Kyncl Pharmacology of tera. Am.J.Med. 1986 PMID: 2872801