Tempol
Tocris Bioscience, part of Bio-Techne | Catalog # 3082
Superoxide scavenger; antioxidant
Key Product Details
Description
Superoxide scavenger; antioxidant
Product Description
Tempol is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Tempol reduces γ-radiation-induced damage in hematopoietic stem cells in vitro and in vivo.Product Specifications
Molecular Weight
172.24
Formula
C9H18NO2
Storage
Store at -20°C
Purity
≥98%
Chemical Name
1-Oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine
CAS Number
2226-96-2
PubChem ID
137994
InChI Key
UZFMOKQJFYMBGY-UHFFFAOYSA-N
SMILES
CC1(C)CC(O)CC(C)(C)N1[O]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.22 | 100 | |
| Ethanol | 17.22 | 100 |
Preparing Stock Solutions
for Tempol
The following data is based on the product molecular weight 172.24
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.81 mL | 29.03 mL | 58.06 mL |
| 5 mM | 1.16 mL | 5.81 mL | 11.61 mL |
| 10 mM | 0.58 mL | 2.90 mL | 5.81 mL |
| 50 mM | 0.12 mL | 0.58 mL | 1.16 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ramachandran Prevention of γ-radiation induced cellular genotoxicity by tempol: Protection of hematopoietic system. Environ.Toxicol.Pharmacol. 2012 PMID: 22609778
- Deng-Bryant Neuroprotective effect of tempol, a catalytic scavenger of peroxynitrite-derived free radicals, in a mouse traumatic brain injury model. J.Cereb.Blood Flow Metab. 2008 PMID: 18319733
- Khattab TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion. EurJ.Pharmacol. 2006 PMID: 16973155
- Francis and Sehgal The superoxide scavenger TEMPOL induces urok. receptor (uPAR) expression in human prostate cancer cells. Mol.Cancer 2006 PMID: 16756681
Product Specific Notices for Tempol
For research use only
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