TCS PIM-1 1

Name: TCS PIM-1 1
Brand: Tocris Bioscience
SKU: 2979

Tocris Bioscience, part of Bio-Techne | Catalog # 2979

Citations (4)

COA / SDS

Selective, ATP-competitive Pim-1 kinase inhibitor

Key Product Details

Description:	Selective, ATP-competitive Pim-1 kinase inhibitor
Alternative Names:	SC 204330
Chemical Name:	3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
Purity:	≥98% (HPLC)
Molecular Weight:	367.2

View Full Technical Details for TCS PIM-1 1

Technical Data
Citations

Biological Activity for TCS PIM-1 1

TCS PIM-1 1 is an ATP-competitive Pim-1 kinase inhibitor that displays selectivity over Pim-2 and MEK1/2 (IC₅₀ values are 50, > 20000 and > 20000 nM for Pim-1, Pim-2 and MEK1/2 respectively).

Compound Libraries for TCS PIM-1 1

TCS PIM-1 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for TCS PIM-1 1

M. Wt	367.2
Formula	C₁₈H₁₁BrN₂O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	491871-58-0
PubChem ID	1235170
InChi Key	SVSYJTYGPLVUOZ-UHFFFAOYSA-N
Smiles	OC1=C(C2=CC(C3=CC=CC=C3)=C(C#N)C(N2)=O)C=C(Br)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TCS PIM-1 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.72	100

Preparing Stock Solutions for TCS PIM-1 1

The following data is based on the product molecular weight 367.2.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.72 mL	13.62 mL	27.23 mL
5 mM	0.54 mL	2.72 mL	5.45 mL
10 mM	0.27 mL	1.36 mL	2.72 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for TCS PIM-1 1

References are publications that support the biological activity of the product.

Cheney Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg.Med.Chem.Letts. 2007 PMID: 17251021