TCS JNK 5a
Tocris Bioscience, part of Bio-Techne | Catalog # 2827
Selective inhibitor of JNK2 and JNK3
Key Product Details
Description
Selective inhibitor of JNK2 and JNK3
Product Description
TCS JNK 5a is a selective inhibitor of JNK2 and JNK3 (pIC50 values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α respectively). Displays no significant activity at a range of other protein kinases including EGFR, ErbB2, cdk2, PLK-1 and Src (pIC50 < 5.0).Product Specifications
Molecular Weight
332.42
Formula
C20H16N2OS
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide
CAS Number
312917-14-9
PubChem ID
766949
InChI Key
WQGDQGAFSDMBLA-UHFFFAOYSA-N
SMILES
O=C(C3=CC=CC4=C3C=CC=C4)NC2=C(C#N)C1=C(S2)CCCC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.24 | 100 |
Preparing Stock Solutions
for TCS JNK 5a
The following data is based on the product molecular weight 332.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.04 mL | 30.08 mL |
| 5 mM | 0.60 mL | 3.01 mL | 6.02 mL |
| 10 mM | 0.30 mL | 1.50 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Angell N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg.Med.Chem.Letts. 2007 PMID: 17194588
Product Specific Notices for TCS JNK 5a
For research use only
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