TCS JNK 5a

Name: TCS JNK 5a
Brand: Tocris Bioscience
SKU: 2827

Tocris Bioscience, part of Bio-Techne | Catalog # 2827

COA / SDS

Selective inhibitor of JNK2 and JNK3

Key Product Details

Description:	Selective inhibitor of JNK2 and JNK3
Chemical Name:	N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	332.42

View Full Technical Details for TCS JNK 5a

Technical Data
Citations

Biological Activity for TCS JNK 5a

TCS JNK 5a is a selective inhibitor of JNK2 and JNK3 (pIC₅₀ values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α respectively). Displays no significant activity at a range of other protein kinases including EGFR, ErbB2, cdk2, PLK-1 and Src (pIC₅₀ < 5.0).

Compound Libraries for TCS JNK 5a

TCS JNK 5a is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for TCS JNK 5a

M. Wt	332.42
Formula	C₂₀H₁₆N₂OS
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	312917-14-9
PubChem ID	766949
InChi Key	WQGDQGAFSDMBLA-UHFFFAOYSA-N
Smiles	O=C(C3=CC=CC4=C3C=CC=C4)NC2=C(C#N)C1=C(S2)CCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TCS JNK 5a

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.24	100

Preparing Stock Solutions for TCS JNK 5a

The following data is based on the product molecular weight 332.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.01 mL	15.04 mL	30.08 mL
5 mM	0.60 mL	3.01 mL	6.02 mL
10 mM	0.30 mL	1.50 mL	3.01 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for TCS JNK 5a

References are publications that support the biological activity of the product.

Angell N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg.Med.Chem.Letts. 2007 PMID: 17194588