TCS ERK 11e
Tocris Bioscience, part of Bio-Techne | Catalog # 4465
Potent and selective ERK2 inhibitor
Key Product Details
Description
Potent and selective ERK2 inhibitor
Alternative Names
VX 11e
Product Description
TCS ERK 11e is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM). Orally bioavailable.Product Specifications
Molecular Weight
500.35
Formula
C24H20Cl2FN5O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[2-[(2-Chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide
CAS Number
896720-20-0
PubChem ID
11634725
InChI Key
WUTVMXLIGHTZJC-OAQYLSRUSA-N
SMILES
O=C(N[C@H](CO)C3=CC(Cl)=CC=C3)C1=CC(C2=NC(NC4=CC=C(F)C=C4Cl)=NC=C2C)=CN1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.03 | 100 | |
| Ethanol | 12.51 | 25 |
Preparing Stock Solutions
for TCS ERK 11e
The following data is based on the product molecular weight 500.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.00 mL | 9.99 mL | 19.99 mL |
| 5 mM | 0.40 mL | 2.00 mL | 4.00 mL |
| 10 mM | 0.20 mL | 1.00 mL | 2.00 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Aronov Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-related kinase (ERK) using conformational control. J.Med.Chem. 2009 PMID: 19827834
Product Specific Notices for TCS ERK 11e
For research use only
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