TCS 401

Name: TCS 401
Brand: Tocris Bioscience
SKU: 2754

Tocris Bioscience, part of Bio-Techne | Catalog # 2754

Citations (6)

COA / SDS

Selective inhibitor of PTP1B

Discontinued Product

2754 has been discontinued. View all Protein Tyrosine Phosphatase Inhibitors products.

Key Product Details

Description:	Selective inhibitor of PTP1B
Chemical Name:	2-[(Carboxycarbonyl)amino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	306.72

View Full Technical Details for TCS 401

Technical Data
Citations

Biological Activity for TCS 401

TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (K_i values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μM for PTP1B, CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1 and LAR D1D2 respectively).

Technical Data for TCS 401

M. Wt	306.72
Formula	C₁₀H₁₀N₂O₅S.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	243966-09-8
PubChem ID	56972185
InChi Key	LQGCAMWQDSYOAY-UHFFFAOYSA-N
Smiles	O=C(C(O)=O)NC2=C(C(O)=O)C1=C(S2)CNCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for TCS 401

References are publications that support the biological activity of the product.

Andersen Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B. J.Med.Chem. 2002 PMID: 12238924
Iversen Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J.Biol.Chem. 2000 PMID: 10744717

TCS 401

Tocris Bioscience, part of Bio-Techne | Catalog # 2754

Key Product Details

Biological Activity for TCS 401

Technical Data for TCS 401

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for TCS 401

Product Documents for TCS 401

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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