TCS 359
Tocris Bioscience, part of Bio-Techne | Catalog # 2591
Potent FLT3 inhibitor
Product Description
TCS 359 is a potent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukemia cell line expressing a constitutively active mutant FLT3 (IC50 = 340 nM).Product Specifications
Molecular Weight
360.43
Formula
C18H20N2O4S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-benzo[b]thiophene-3-carboxamide
CAS Number
301305-73-7
PubChem ID
1048845
InChI Key
FSPQCTGGIANIJZ-UHFFFAOYSA-N
SMILES
COC1=CC=C(C=C1OC)C(=O)NC1=C(C(N)=O)C2=C(CCCC2)S1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.81 | 30 |
Preparing Stock Solutions
for TCS 359
The following data is based on the product molecular weight 360.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.3 mM | 9.25 mL | 46.24 mL | 92.48 mL |
| 1.5 mM | 1.85 mL | 9.25 mL | 18.50 mL |
| 3 mM | 0.92 mL | 4.62 mL | 9.25 mL |
| 15 mM | 0.18 mL | 0.92 mL | 1.85 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Patch Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg.Med.Chem.Lett. 2006 PMID: 16580199
Product Specific Notices for TCS 359
For research use only
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