TCS 2312
Tocris Bioscience, part of Bio-Techne | Catalog # 3038
Potent Chk1 inhibitor
Discontinued Product
3038 has been discontinued.
View all Checkpoint Kinase Inhibitors products.
Product Description
TCS 2312 is a potent and selective checkpoint kinase 1 (chk1) inhibitor (Ki = 0.38 nM, EC50 = 60 nM). Enhances the cell killing activity of Gemcitabine (Cat. No. 3259) in breast and prostate cancer cell lines and displays antiproliferative effects in vitro.Product Specifications
Molecular Weight
412.48
Formula
C25H24N4O2
Storage
Store at -80°C
Purity
≥97% (HPLC)
Chemical Name
4'-[5-[[3-[(Cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]-[1,1'-biphenyl]-2,4-diol
CAS Number
838823-31-7
PubChem ID
11258443
InChI Key
BYFCMDWKTJJQGR-UHFFFAOYSA-N
SMILES
OC1=CC(O)=CC=C1C2=CC=C(C3=CC(NC4=CC=C(CNC5CC5)C=C4)=NN3)C=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.25 | 20 |
Preparing Stock Solutions
for TCS 2312
The following data is based on the product molecular weight 412.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.12 mL | 60.61 mL | 121.22 mL |
| 1 mM | 2.42 mL | 12.12 mL | 24.24 mL |
| 2 mM | 1.21 mL | 6.06 mL | 12.12 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Teng Structure-based design of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors. J.Med.Chem. 2007 PMID: 17887663
Product Specific Notices for TCS 2312
For research use only
Loading...
Loading...