TC-S 7003
Tocris Bioscience, part of Bio-Techne | Catalog # 3567
Potent Lck inhibitor
Product Description
TC-S 7003 is a potent inhibitor of lymphocyte specific kinase (Lck). IC50 values are 0.007, 0.021, 0.042 and 0.20 μM for Lck, Lyn, Src and Syk kinases respectively. Displays >1000-fold selectivity for Lck over MAPK, CDK and RSK family representatives. Inhibits T cell proliferation in vitro and inhibits arthritis in two in vivo models. Orally active.Product Specifications
Molecular Weight
530.62
Formula
C31H30N8O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6-(2,6-Dimethylphenyl)-2-[[4-(4-methyl-1-pyrimidopyrimido[1,2-a]benzimidazol-5(6H)-one
CAS Number
847950-09-8
PubChem ID
11785878
InChI Key
BHJJWVDKNXABFS-UHFFFAOYSA-N
SMILES
O=C3N(C4=C(C)C=CC=C4C)C1=NC7=C(C=CC=C7)N1C2=NC(NC5=CC=C(N6CCN(C)CC6)C=C5)=NC=C23
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.06 | 100 | |
| Ethanol | 5.31 | 10 with gentle warming |
Preparing Stock Solutions
for TC-S 7003
The following data is based on the product molecular weight 530.62
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.88 mL | 9.42 mL | 18.85 mL |
| 5 mM | 0.38 mL | 1.88 mL | 3.77 mL |
| 10 mM | 0.19 mL | 0.94 mL | 1.88 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for TC-S 7003
For research use only
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