TC-I 2000

Name: TC-I 2000
Brand: Tocris Bioscience
SKU: 4632

Tocris Bioscience, part of Bio-Techne | Catalog # 4632

COA / SDS

TRPM8 blocker

Key Product Details

Description:	TRPM8 blocker
Chemical Name:	N-(4-Fluorophenyl)-3,4-dihydro-1-[4-(trifluoromethyl)phenyl]-2(1H)-isoquinolinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	414.4

View Full Technical Details for TC-I 2000

Technical Data
Citations

Biological Activity for TC-I 2000

TC-I 2000 is a tRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells (IC₅₀ = 53 nM).

Compound Libraries for TC-I 2000

TC-I 2000 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TC-I 2000

M. Wt	414.4
Formula	C₂₃H₁₈F₄N₂O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1159996-20-9
PubChem ID	57326210
InChi Key	ADCDUDFEGFKKQH-UHFFFAOYSA-N
Smiles	O=C(NC3=CC=C(F)C=C3)N2C(C4=CC=C(C(F)(F)F)C=C4)C1=CC=CC=C1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC-I 2000

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.44	100
	ethanol	8.29	20

Preparing Stock Solutions for TC-I 2000

The following data is based on the product molecular weight 414.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.07 mL	24.13 mL
5 mM	0.48 mL	2.41 mL	4.83 mL
10 mM	0.24 mL	1.21 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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Reconstitution Calculator

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References for TC-I 2000

References are publications that support the biological activity of the product.

Tamayo Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists. J.Med.Chem. 2012 PMID: 22329507