TC-I 2000
Tocris Bioscience, part of Bio-Techne | Catalog # 4632
TRPM8 blocker
Product Description
TC-I 2000 is a tRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells (IC50 = 53 nM).Product Specifications
Molecular Weight
414.40
Formula
C23H18F4N2O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(4-Fluorophenyl)-3,4-dihydro-1-[4-(trifluoromethyl)phenyl]-2(1H)-isoquinolinecarboxamide
CAS Number
1159996-20-9
PubChem ID
57326210
InChI Key
ADCDUDFEGFKKQH-UHFFFAOYSA-N
SMILES
O=C(NC3=CC=C(F)C=C3)N2C(C4=CC=C(C(F)(F)F)C=C4)C1=CC=CC=C1CC2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.44 | 100 | |
| Ethanol | 8.29 | 20 |
Preparing Stock Solutions
for TC-I 2000
The following data is based on the product molecular weight 414.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.41 mL | 12.07 mL | 24.13 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.83 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.41 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Tamayo Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists. J.Med.Chem. 2012 PMID: 22329507
Product Specific Notices for TC-I 2000
For research use only
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