TC-G 1004
Tocris Bioscience, part of Bio-Techne | Catalog # 4407
Potent and selective A2A antagonist
Key Product Details
Description
Potent and selective A2A antagonist
Product Description
TC-G 1004 is a potent antagonist of adenosine A2A receptors; displays >100-fold selectivity for A2A over A1 receptors (Ki values are 0.44 and 85 nM respectively). Potentiates L-DOPA-induced rotational behavior in 6-OHDA-lesioned rats.Product Specifications
Molecular Weight
421.50
Formula
C22H27N7O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methoxy-1-piperidinyl)-2-pyridinyl]-4-pyrimidinyl]acetamide
CAS Number
1061747-72-5
PubChem ID
25074316
InChI Key
JENSDTKXNVHSSN-UHFFFAOYSA-N
SMILES
CC1=CC(C)=NN1C2=NC(C3=CC=CC(N4CCC(OC)CC4)=N3)=CC(NC(C)=O)=N2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 42.15 | 100 | |
| DMSO | 42.15 | 100 |
Preparing Stock Solutions
for TC-G 1004
The following data is based on the product molecular weight 421.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.37 mL | 11.86 mL | 23.72 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.74 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.37 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for TC-G 1004
For research use only
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