TC-G 1004

Name: TC-G 1004
Brand: Tocris Bioscience
SKU: 4407

Tocris Bioscience, part of Bio-Techne | Catalog # 4407

COA / SDS

Potent and selective A2A antagonist

Key Product Details

Description:	Potent and selective A_2A antagonist
Chemical Name:	N-[2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methoxy-1-piperidinyl)-2-pyridinyl]-4-pyrimidinyl]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	421.5

View Full Technical Details for TC-G 1004

Technical Data
Citations

Biological Activity for TC-G 1004

TC-G 1004 is a potent antagonist of adenosine A_2A receptors; displays >100-fold selectivity for A_2A over A₁ receptors (K_i values are 0.44 and 85 nM respectively). Potentiates L-DOPA-induced rotational behavior in 6-OHDA-lesioned rats.

Technical Data for TC-G 1004

M. Wt	421.5
Formula	C₂₂H₂₇N₇O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1061747-72-5
PubChem ID	25074316
InChi Key	JENSDTKXNVHSSN-UHFFFAOYSA-N
Smiles	CC1=CC(C)=NN1C2=NC(C3=CC=CC(N4CCC(OC)CC4)=N3)=CC(NC(C)=O)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC-G 1004

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	42.15	100
	DMSO	42.15	100

Preparing Stock Solutions for TC-G 1004

The following data is based on the product molecular weight 421.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.86 mL	23.72 mL
5 mM	0.47 mL	2.37 mL	4.74 mL
10 mM	0.24 mL	1.19 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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References for TC-G 1004

References are publications that support the biological activity of the product.

Zhang Lead optimization of 4-acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A_2A adenosine receptor antagonists for the treatment of Parkinson's disease. J.Med.Chem. 2008 PMID: 18947224