TC-FPR 43
Tocris Bioscience, part of Bio-Techne | Catalog # 4624
Potent FPR2 agonist
Product Description
TC-FPR 43 is a potent formyl peptide receptor 2 (FPR2) agonist (EC50 = 44 nM). Inhibits fMLP- and IL-8-induced neutrophil migration. Suppresses inflammation in a mouse model of acute inflammation. Orally bioavailable.Product Specifications
Molecular Weight
384.86
Formula
C20H21ClN4O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(4-Chlorophenyl)-N-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea
CAS Number
903895-98-7
PubChem ID
24776341
InChI Key
PAEBEUZTAPIOIO-UHFFFAOYSA-N
SMILES
CC(C)C1=C(NC(NC3=CC=C(Cl)C=C3)=O)C(N(C2=CC=CC=C2)N1C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.49 | 100 |
Preparing Stock Solutions
for TC-FPR 43
The following data is based on the product molecular weight 384.86
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.60 mL | 12.99 mL | 25.98 mL |
| 5 mM | 0.52 mL | 2.60 mL | 5.20 mL |
| 10 mM | 0.26 mL | 1.30 mL | 2.60 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bürli Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Bioorg.Med.Chem.Lett. 2006 PMID: 16697190
- Forsman Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library. Biochem.Pharmacol. 2011 PMID: 21095183
- Dufton Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. J.Immunol. 2010 PMID: 20107188
Product Specific Notices for TC-FPR 43
For research use only
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