TC-F 2

Name: TC-F 2
Brand: Tocris Bioscience
SKU: 4355

Tocris Bioscience, part of Bio-Techne | Catalog # 4355

Citations (2)

COA / SDS

Potent, reversible and selective FAAH inhibitor

Key Product Details

Description:	Potent, reversible and selective FAAH inhibitor
Chemical Name:	1-[(3S)-1-[4-(2-Benzofuranyl)-2-pyrimidinyl]-3-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	439.51

View Full Technical Details for TC-F 2

Technical Data
Citations

Biological Activity for TC-F 2

TC-F 2 is a potent, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC₅₀ values are 28 and 100 nM for human and rat FAAH respectively). Noncovalent inhibitor; displays selectivity for FAAH over cannabinoid-related targets (IC₅₀ > 20 μM for CB₁, CB₂ and TRPV1). Active in vivo.

Compound Libraries for TC-F 2

TC-F 2 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TC-F 2

M. Wt	439.51
Formula	C₂₆H₂₅N₅O₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1304778-15-1
PubChem ID	25198728
InChi Key	NXTBLPPTZRPJCA-IBGZPJMESA-N
Smiles	O=C(N(CC)C6=C5C=CC=C6)N5[C@H]1CCCN(C2=NC(C3=CC(C=CC=C4)=C4O3)=CC=N2)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC-F 2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.95	100

Preparing Stock Solutions for TC-F 2

The following data is based on the product molecular weight 439.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.38 mL	22.75 mL
5 mM	0.46 mL	2.28 mL	4.55 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for TC-F 2

References are publications that support the biological activity of the product.

Gustin Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors. Bioorg.Med.Chem.Lett. 2011 PMID: 21392988
Min Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH). Proc.Natl.Acad.Sci.U.S.A. 2011 PMID: 21502526