TB 21007
Tocris Bioscience, part of Bio-Techne | Catalog # 2905
α5-selective GABAA inverse agonist
Key Product Details
Description
α5-selective GABAA inverse agonist
Product Description
TB 21007 is a GABAA receptor inverse agonist selective for the α5-subtype (Ki values are 1.6, 16, 20 and 20 nM for α5, α2, α1 and α3 subtypes respectively). Brain penetrant; enhances cognitive performance in rats in the delayed matching-to-place morris water maze test following i.p. administration.Product Specifications
Molecular Weight
339.50
Formula
C15H17NO2S3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
6,7-Dihydro-3-[(2-hydroxyethyl)thio]-6,6-dimethyl-1-(2-thiazolyl)-benzo[c]thiophen-4(5H)-one
CAS Number
207306-50-1
PubChem ID
6918633
InChI Key
QILRYFCEXLFIDS-UHFFFAOYSA-N
SMILES
O=C2C1=C(SCCO)SC(C3=NC=CS3)=C1CC(C)(C)C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.95 | 100 | |
| Ethanol | 8.49 | 25 |
Preparing Stock Solutions
for TB 21007
The following data is based on the product molecular weight 339.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.95 mL | 14.73 mL | 29.46 mL |
| 5 mM | 0.59 mL | 2.95 mL | 5.89 mL |
| 10 mM | 0.29 mL | 1.47 mL | 2.95 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chambers Identification of a novel, selective GABA5 α5 receptor inverse agonist which enhances cognition. J.Med.Chem. 2003 PMID: 12747794
Product Specific Notices for TB 21007
For research use only
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