TB 21007

Name: TB 21007
Brand: Tocris Bioscience
SKU: 2905

Tocris Bioscience, part of Bio-Techne | Catalog # 2905

Citations (7)

COA / SDS

α5-selective GABAA inverse agonist

Key Product Details

Description:	α5-selective GABA_A inverse agonist
Chemical Name:	6,7-Dihydro-3-[(2-hydroxyethyl)thio]-6,6-dimethyl-1-(2-thiazolyl)-benzo[c]thiophen-4(5H)-one
Purity:	≥98% (HPLC)
Molecular Weight:	339.5

View Full Technical Details for TB 21007

Technical Data
Citations

Biological Activity for TB 21007

TB 21007 is a GABA_A receptor inverse agonist selective for the α₅-subtype (K_i values are 1.6, 16, 20 and 20 nM for α5, α2, α1 and α3 subtypes respectively). Brain penetrant; enhances cognitive performance in rats in the delayed matching-to-place morris water maze test following i.p. administration.

Technical Data for TB 21007

M. Wt	339.5
Formula	C₁₅H₁₇NO₂S₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	207306-50-1
PubChem ID	6918633
InChi Key	QILRYFCEXLFIDS-UHFFFAOYSA-N
Smiles	O=C2C1=C(SCCO)SC(C3=NC=CS3)=C1CC(C)(C)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TB 21007

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.95	100
	ethanol	8.49	25

Preparing Stock Solutions for TB 21007

The following data is based on the product molecular weight 339.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.95 mL	14.73 mL	29.46 mL
5 mM	0.59 mL	2.95 mL	5.89 mL
10 mM	0.29 mL	1.47 mL	2.95 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for TB 21007

References are publications that support the biological activity of the product.

Chambers Identification of a novel, selective GABA₅ α5 receptor inverse agonist which enhances cognition. J.Med.Chem. 2003 PMID: 12747794