TAT-SAMβA Peptide

Name: TAT-SAMβA Peptide
Brand: Tocris Bioscience
SKU: 7962

Tocris Bioscience, part of Bio-Techne | Catalog # 7962

COA / SDS

Selective antagonist of Mfn1-βIIPKC association

Key Product Details

Description:	Selective antagonist of Mfn1-βIIPKC association
Purity:	≥95% (HPLC)
Molecular Weight:	2824.16

View Full Technical Details for TAT-SAMβA Peptide

Technical Data
Citations

Biological Activity for TAT-SAMβA Peptide

TAT-SAMβA Peptide is a selective antagonist of Mfn1-βIIPKC association. Comprises the cell permeable peptide TAT47-57, conjugated to βIIPKC624-632 by a Gly-Gly spacer. TAT-SAMβA Peptide reduces mitochondrial fragmentation and stress-induced death in cultured cardiomyocytes. In rats with heart failure, TAT-SAMβA Peptide restores mitochondrial morphology, bioenergetics, and redox balance, which leads to improvement in cardiac contractility.

Technical Data for TAT-SAMβA Peptide

M. Wt	2824.16
Formula	C₁₁₈H₁₉₅N₅₁O₃₁
Single Letter Sequence	YGRKKRRQRRRGGRNAENFDRF
Storage	Store at -20°C
Purity	≥95% (HPLC)
InChi Key	RGMNLQQBUQABCW-OODSNGTQSA-N
Smiles	O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCC(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CC=CC=C2)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC3=CC=C(C=C3)O)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TAT-SAMβA Peptide

Solubility

Soluble to 2mg/ml in water

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References for TAT-SAMβA Peptide

References are publications that support the biological activity of the product.

Zacharioudakis Mitochondrial dynamics proteins as emerging drug targets. Trends Pharmacol.Sci. 2022 PMID: 36496299
Ferreira A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. Nat.Commun. 2019 PMID: 30659190