TAT-Gap19(I130A)

Name: TAT-Gap19(I130A)
Brand: Tocris Bioscience
SKU: 7402

Tocris Bioscience, part of Bio-Techne | Catalog # 7402

COA / SDS

Control peptide for TAT-Gap19

Key Product Details

Description:	Control peptide for TAT-Gap19
Purity:	≥95% (HPLC)
Molecular Weight:	2661.2

View Full Technical Details for TAT-Gap19(I130A)

Technical Data
Citations

Biological Activity for TAT-Gap19(I130A)

TAT-Gap19(I130A) is a control peptide for TAT-Gap19 (Cat. No. 6227), a Cx43 hemichannel blocker. TAT-Gap19(I130A) consists of TAT-GAP19 with a I130A amino acid residue change at a key residue for GAP19 activity. In C6 glioma cells expression Cx43, TAT-GAP19(1130A) does not inhibit [Ca²⁺]_i-triggered ATP release at 200 μM. TAT-Gap19(I130A) is cell permeable.

Technical Data for TAT-Gap19(I130A)

M. Wt	2661.2
Formula	C₁₁₆H₂₀₆N₄₆O₂₆
Single Letter Sequence	YGRKKRRQRRRKQAEIKKFK
Storage	Store at -20°C
Purity	≥95% (HPLC)
InChi Key	JIFBPYPLZXITDC-KYILVESISA-N
Smiles	O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=C(C=C2)O)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TAT-Gap19(I130A)

Solubility

Soluble to 2mg/ml in water

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References for TAT-Gap19(I130A)

References are publications that support the biological activity of the product.

Walrave Inhibition of connexin43 hemichannels impairs spatial short-term memory without affecting spatial working memory. Front.Cell Neurosci. 2016 PMID: 28066184
Wang Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res.Cardiol. 2013 PMID: 23184389