TAT-cyclo-CLLFVY

Tocris Bioscience, part of Bio-Techne | Catalog # 5582

Selective HIF-1 dimerization inhibitor
Discontinued Product
5582 has been discontinued. View all HIF Inhibitors products.

Key Product Details

Description

Selective HIF-1 dimerization inhibitor

View all HIF Inhibitors »

Product Description

TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM) . Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.

Product Specifications

Molecular Weight

2559.10

Formula

C111H188N42O24S2

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

1446322-66-2

PubChem ID

72192490

InChI Key

AWUUHEHYNQGEFC-XLZVTALKSA-N

SMILES

[H]N[C@@H](CSSC[C@@H]1N([H])C(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Product Documents for TAT-cyclo-CLLFVY

Certificate of Analysis

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Product Specific Notices for TAT-cyclo-CLLFVY

For research use only

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